Gene library · Pharmacogenomics
TPMT metabolism (*3B)
rs1800460 · gene TPMT · category Pharmacogenomics · Quanome Plus
Your DNA file reports your genotype at rs1800460 — a marker in the TPMT gene that studies link to tpmt metabolism (*3b). Here's what each genotype is associated with:
| Genotype | What it's associated with |
|---|---|
| CC | Normal TPMT activity at this marker — typical metabolism of thiopurines (azathioprine, mercaptopurine). |
| CT | One reduced-function *3B allele — intermediate TPMT activity; standard thiopurine doses may need lowering. Informational. |
| TT | Two reduced-function alleles — low TPMT activity; high toxicity risk from standard thiopurine doses. Informational only; dosing is a clinical decision. |
Want to read rs1800460 in your own data? The free DNA explorer checks it in your browser — nothing is uploaded. Or get the full picture in Quanome, which reads your whole genome on-device alongside your labs and Apple Health.
