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Gene library · Pharmacogenomics

TPMT metabolism (*3B)

rs1800460 · gene TPMT · category Pharmacogenomics · Quanome Plus

Your DNA file reports your genotype at rs1800460 — a marker in the TPMT gene that studies link to tpmt metabolism (*3b). Here's what each genotype is associated with:

GenotypeWhat it's associated with
CCNormal TPMT activity at this marker — typical metabolism of thiopurines (azathioprine, mercaptopurine).
CTOne reduced-function *3B allele — intermediate TPMT activity; standard thiopurine doses may need lowering. Informational.
TTTwo reduced-function alleles — low TPMT activity; high toxicity risk from standard thiopurine doses. Informational only; dosing is a clinical decision.

Educational only — not medical or diagnostic advice. A single marker is one of many factors; strand orientation varies between files. Always consult a qualified clinician about your health.

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