Gene library · Pharmacogenomics
UGT1A1 activity (bilirubin, irinotecan)
rs887829 · gene UGT1A1 · category Pharmacogenomics · Quanome Plus
Your DNA file reports your genotype at rs887829 — a marker in the UGT1A1 gene that studies link to ugt1a1 activity (bilirubin, irinotecan). Here's what each genotype is associated with:
| Genotype | What it's associated with |
|---|---|
| CC | Typical UGT1A1 activity — normal bilirubin handling and usual metabolism of drugs like irinotecan and atazanavir. |
| CT | One reduced-activity allele — mildly lower UGT1A1 activity; bilirubin may run slightly high. Usually benign (Gilbert-type). |
| TT | Two reduced-activity alleles — lower UGT1A1 activity (Gilbert pattern); higher bilirubin and increased toxicity risk from irinotecan/atazanavir. Informational; discuss before those drugs. |
Want to read rs887829 in your own data? The free DNA explorer checks it in your browser — nothing is uploaded. Or get the full picture in Quanome, which reads your whole genome on-device alongside your labs and Apple Health.
