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Gene library · Pharmacogenomics

UGT1A1 activity (bilirubin, irinotecan)

rs887829 · gene UGT1A1 · category Pharmacogenomics · Quanome Plus

Your DNA file reports your genotype at rs887829 — a marker in the UGT1A1 gene that studies link to ugt1a1 activity (bilirubin, irinotecan). Here's what each genotype is associated with:

GenotypeWhat it's associated with
CCTypical UGT1A1 activity — normal bilirubin handling and usual metabolism of drugs like irinotecan and atazanavir.
CTOne reduced-activity allele — mildly lower UGT1A1 activity; bilirubin may run slightly high. Usually benign (Gilbert-type).
TTTwo reduced-activity alleles — lower UGT1A1 activity (Gilbert pattern); higher bilirubin and increased toxicity risk from irinotecan/atazanavir. Informational; discuss before those drugs.

Educational only — not medical or diagnostic advice. A single marker is one of many factors; strand orientation varies between files. Always consult a qualified clinician about your health.

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