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Gene library · Pharmacogenomics

Thiopurine metabolism (*3C)

rs1142345 · gene TPMT · category Pharmacogenomics · Quanome Plus

Your DNA file reports your genotype at rs1142345 — a marker in the TPMT gene that studies link to thiopurine metabolism (*3c). Here's what each genotype is associated with:

GenotypeWhat it's associated with
AANormal TPMT activity.
AGIntermediate TPMT — thiopurine drugs may need dose care. Informational.
GGLow TPMT — thiopurines can accumulate. Informational; clinically managed by your doctor.

Educational only — not medical or diagnostic advice. A single marker is one of many factors; strand orientation varies between files. Always consult a qualified clinician about your health.

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