Gene library · Pharmacogenomics
Thiopurine metabolism (*3C)
rs1142345 · gene TPMT · category Pharmacogenomics · Quanome Plus
Your DNA file reports your genotype at rs1142345 — a marker in the TPMT gene that studies link to thiopurine metabolism (*3c). Here's what each genotype is associated with:
| Genotype | What it's associated with |
|---|---|
| AA | Normal TPMT activity. |
| AG | Intermediate TPMT — thiopurine drugs may need dose care. Informational. |
| GG | Low TPMT — thiopurines can accumulate. Informational; clinically managed by your doctor. |
Want to read rs1142345 in your own data? The free DNA explorer checks it in your browser — nothing is uploaded. Or get the full picture in Quanome, which reads your whole genome on-device alongside your labs and Apple Health.
