Gene library · Pharmacogenomics
NUDT15 metabolism (*3)
rs116855232 · gene NUDT15 · category Pharmacogenomics · Quanome Plus
Your DNA file reports your genotype at rs116855232 — a marker in the NUDT15 gene that studies link to nudt15 metabolism (*3). Here's what each genotype is associated with:
| Genotype | What it's associated with |
|---|---|
| CC | Normal NUDT15 (*1) — typical metabolism of thiopurine drugs (azathioprine, mercaptopurine). |
| CT | One reduced-function *3 copy (intermediate metabolizer) — higher sensitivity to thiopurines. Informational; dosing is a clinical decision. |
| TT | Two *3 copies (poor metabolizer) — markedly higher thiopurine toxicity risk. Informational; discuss with a professional. |
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