Gene library · Pharmacogenomics
Fluoropyrimidine metabolism (*2A)
rs3918290 · gene DPYD · category Pharmacogenomics · Quanome Plus
Your DNA file reports your genotype at rs3918290 — a marker in the DPYD gene that studies link to fluoropyrimidine metabolism (*2a). Here's what each genotype is associated with:
| Genotype | What it's associated with |
|---|---|
| CC | Normal DPD activity. |
| CT | Reduced DPD — higher toxicity risk with 5-FU/capecitabine chemo. Informational; clinically critical, discuss with your oncologist. |
| TT | DPD deficiency — serious toxicity risk with these chemo drugs. Informational; clinically critical. |
Want to read rs3918290 in your own data? The free DNA explorer checks it in your browser — nothing is uploaded. Or get the full picture in Quanome, which reads your whole genome on-device alongside your labs and Apple Health.
