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Gene library · Pharmacogenomics

ABCG2 transporter (Q141K)

rs2231142 · gene ABCG2 · category Pharmacogenomics · Quanome Plus

Your DNA file reports your genotype at rs2231142 — a marker in the ABCG2 gene that studies link to abcg2 transporter (q141k). Here's what each genotype is associated with:

GenotypeWhat it's associated with
GGNormal ABCG2 transporter function — typical handling of rosuvastatin and allopurinol.
GTOne reduced-function (141K) allele — somewhat higher rosuvastatin exposure; intermediate. Informational.
TTTwo reduced-function (141K) alleles — higher rosuvastatin levels (lower doses may suffice) and often better allopurinol response. Informational; discuss with a professional.

Educational only — not medical or diagnostic advice. A single marker is one of many factors; strand orientation varies between files. Always consult a qualified clinician about your health.

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