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Gene library · Complex disease risk

Atrial fibrillation risk (4q25)

rs2200733 · gene 4q25 (PITX2) · category Complex disease risk · Quanome Plus

Your DNA file reports your genotype at rs2200733 — a marker in the 4q25 (PITX2) gene that studies link to atrial fibrillation risk (4q25). Here's what each genotype is associated with:

GenotypeWhat it's associated with
CCLower-risk genotype at the 4q25/PITX2 locus, the top common atrial-fibrillation marker — average background risk.
CTOne risk (T) allele — modestly higher atrial-fibrillation risk. Informational; mention palpitations to your doctor if they occur.
TTTwo risk (T) alleles — higher atrial-fibrillation risk at this marker. Informational, not a diagnosis.

Educational only — not medical or diagnostic advice. A single marker is one of many factors; strand orientation varies between files. Always consult a qualified clinician about your health.

Want to read rs2200733 in your own data? The free DNA explorer checks it in your browser — nothing is uploaded. Or get the full picture in Quanome, which reads your whole genome on-device alongside your labs and Apple Health.

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